Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects
Identifieur interne : 000167 ( France/Analysis ); précédent : 000166; suivant : 000168Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects
Auteurs : Louis Cara [France] ; Patrick Borel [France] ; Martine Armand [France] ; Michele Senft [France] ; Huguette Lafont [France] ; Henri Portugal [France] ; Anne-Marie Pauli [France] ; Daniele Boulze [France] ; Christianne Lacombe [France] ; Denis Lairon [France]Source :
- Plant Foods for Human Nutrition [ 0921-9668 ] ; 1991-04-01.
English descriptors
Abstract
Abstract: The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. Ten free-living adult subjects participated in the study. None was obese or diabetic. They all presented an, hypercholesterolemia (from 6.58 to 9.50 mM), associated in 6 over 10 cases to an hypertriglyceridemia (from 1.70 to 5.00 mM). The subjects were studied in three consecutive periods, during which they first were on their usual diet (first week), they then ingested a daily supplement of 30 g wheat germ (4 weeks) and then they returned to their usual basal diet (4 weeks follow-up). Dietary records were obtained for 7 and 3 consecutive days before and during wheat germ supplementation, respectively. Fasting blood samples were taken at the end of each period. After 4 weeks of wheat, germ intake, glycemia did not change while total plasma cholesterol significantly decreased (paired Student'st test,p≤0.05) from 7.80 to 7.15 mM. LDL and HDL cholesterol values did not show marked changes, but VLDL cholesterol significantly dropped by 40.6%. Thus, the plasma/HDL total cholesterol ratio was significantly lower. Apoprotein B and A1 decreased. In the hypertriglyceridemic subjects, this was accompanied by a significant reduction of plasma triglycerides (1.64 vs. 2.68 mM) and a marked drop of VLDL triglycerides (−51%). Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat [40] and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia.
Url:
DOI: 10.1007/BF02194082
Affiliations:
- France
- Languedoc-Roussillon-Midi-Pyrénées, Midi-Pyrénées, Provence-Alpes-Côte d'Azur
- Marseille, Toulouse
- Université Toulouse III - Paul Sabatier
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ISTEX:EB9F782353B66CA4E1AC0F81433EA2708C3F5971Le document en format XML
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from="135">135</biblScope><biblScope unit="page" to="150">150</biblScope></imprint><idno type="ISSN">0921-9668</idno></series><idno type="istex">EB9F782353B66CA4E1AC0F81433EA2708C3F5971</idno><idno type="DOI">10.1007/BF02194082</idno><idno type="ArticleID">Art4</idno><idno type="ArticleID">BF02194082</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0921-9668</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>human</term><term>hypercholesterolemia</term><term>hypertriglyceridemia</term><term>serum lipoproteins</term><term>wheat germ</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. Ten free-living adult subjects participated in the study. None was obese or diabetic. They all presented an, hypercholesterolemia (from 6.58 to 9.50 mM), associated in 6 over 10 cases to an hypertriglyceridemia (from 1.70 to 5.00 mM). The subjects were studied in three consecutive periods, during which they first were on their usual diet (first week), they then ingested a daily supplement of 30 g wheat germ (4 weeks) and then they returned to their usual basal diet (4 weeks follow-up). Dietary records were obtained for 7 and 3 consecutive days before and during wheat germ supplementation, respectively. Fasting blood samples were taken at the end of each period. After 4 weeks of wheat, germ intake, glycemia did not change while total plasma cholesterol significantly decreased (paired Student'st test,p≤0.05) from 7.80 to 7.15 mM. LDL and HDL cholesterol values did not show marked changes, but VLDL cholesterol significantly dropped by 40.6%. Thus, the plasma/HDL total cholesterol ratio was significantly lower. Apoprotein B and A1 decreased. In the hypertriglyceridemic subjects, this was accompanied by a significant reduction of plasma triglycerides (1.64 vs. 2.68 mM) and a marked drop of VLDL triglycerides (−51%). Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat [40] and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon-Midi-Pyrénées</li><li>Midi-Pyrénées</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Cara, Louis" sort="Cara, Louis" uniqKey="Cara L" first="Louis" last="Cara">Louis Cara</name></region><name sortKey="Armand, Martine" sort="Armand, Martine" uniqKey="Armand M" first="Martine" last="Armand">Martine Armand</name><name sortKey="Borel, Patrick" sort="Borel, Patrick" uniqKey="Borel P" first="Patrick" last="Borel">Patrick Borel</name><name sortKey="Boulze, Daniele" sort="Boulze, Daniele" uniqKey="Boulze D" first="Daniele" last="Boulze">Daniele Boulze</name><name sortKey="Lacombe, Christianne" sort="Lacombe, Christianne" uniqKey="Lacombe C" first="Christianne" last="Lacombe">Christianne Lacombe</name><name sortKey="Lafont, Huguette" sort="Lafont, Huguette" uniqKey="Lafont H" first="Huguette" last="Lafont">Huguette Lafont</name><name sortKey="Lairon, Denis" sort="Lairon, Denis" uniqKey="Lairon D" first="Denis" last="Lairon">Denis Lairon</name><name sortKey="Pauli, Anne Marie" sort="Pauli, Anne Marie" uniqKey="Pauli A" first="Anne-Marie" last="Pauli">Anne-Marie Pauli</name><name sortKey="Portugal, Henri" sort="Portugal, Henri" uniqKey="Portugal H" first="Henri" last="Portugal">Henri Portugal</name><name sortKey="Senft, Michele" sort="Senft, Michele" uniqKey="Senft M" first="Michele" last="Senft">Michele Senft</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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